KPNA6 antibody (AA 101-200) (AbBy Fluor® 350)
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- Target See all KPNA6 Antibodies
- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
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Binding Specificity
- AA 101-200
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KPNA6 antibody is conjugated to AbBy Fluor® 350
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse
- Predicted Reactivity
- Rat,Cow,Sheep,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human KPNA6
- Isotype
- IgG
- Top Product
- Discover our top product KPNA6 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))
- Alternative Name
- KPNA6 (KPNA6 Products)
- Synonyms
- IPOA7 antibody, Kpna5 antibody, NPI-2 antibody, KPNA7 antibody, karyopherin subunit alpha 6 antibody, karyopherin (importin) alpha 6 antibody, karyopherin alpha 6 (importin alpha 7) antibody, karyopherin alpha 6 (importin alpha 7) S homeolog antibody, KPNA6 antibody, Kpna6 antibody, kpna6.S antibody
- Background
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Synonyms: Importin subunit alpha-7, KPNA6, Karyopherin subunit alpha-6, KPNA6, IPOA7
Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
- Gene ID
- 23633
- UniProt
- O60684
- Pathways
- Protein targeting to Nucleus
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