TEAD1 antibody

Catalog No. ABIN6972853

Product Details anti-TEAD1 Antibody

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD1 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor)) is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. TEAD1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogen: This antibody was raised against a recombinant protein fragment within human TEAD1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for TEAD1

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Alternative Name: TEAD1 (TEAD1 Products)

Synonyms: tead1 antibody, zgc:63696 antibody, TEAD1 antibody, xtead1 antibody, 2610024B07Rik antibody, B230114H05Rik antibody, Gtrgeo5 antibody, TEAD-1 antibody, TEF-1 antibody, Tcf13 antibody, mTEF-1 antibody, AA antibody, NTEF-1 antibody, REF1 antibody, TCF-13 antibody, TCF13 antibody, XNTEF-1 antibody, xlNTEF-1 antibody, TEA domain family member 1a antibody, TEA domain transcription factor 1 antibody, TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody, TEA domain family member 1 antibody, TEA domain family member 1 (SV40 transcriptional enhancer factor) S homeolog antibody, TEA domain family member 1b antibody, tead1a antibody, TEAD1 antibody, tead1 antibody, Tead1 antibody, tead1.S antibody, tead1b antibody

Molecular Weight: 60 kDa

NCBI Accession: NP_068780

Pathways: Regulation of Lipid Metabolism by PPARalpha