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N6-Methyladenosine antibody

Reactivity: Human, Saccharomyces cerevisiae DB, IP Host: Mouse Monoclonal 17-3-4-1 unconjugated
Catalog No. ABIN6972397
  • Target
    N6-Methyladenosine
    Reactivity
    Human, Saccharomyces cerevisiae
    Host
    • 1
    • 1
    Mouse
    Clonality
    • 1
    • 1
    Monoclonal
    Conjugate
    • 2
    Un-conjugated
    Application
    Dot Blot (DB), Immunoprecipitation (IP)
    Characteristics
    N6-Methyladenosine (m6A) ) is an RNA modification on the N-6 position of adenosine. This modification has been found to be abundant in the 3' UTR and stop codons of mammalian mRNA. m6A is associated with miRNA binding sites suggesting a potential role in epigenetic gene regulation. FTO and ALKBH are demethylases for 6-methyladenosine while a multiprotein complex that includes METTL3 functions as the methyltransferase. Recent findings revealed that m6A is also present on metazoan DNA, suggesting a genuine epigenetic role for this modification in the context of DNA as well. N6-Methyladenosine (m6A) antibody (mAb) (Clone 17-3-4-1) was raised in a Mouse host. It has been validated for use in Dot blot and Immunoprecipitation, it has been shown to react with Budding Yeast and Human samples, but the sequence is not species specific so it should react with a wide range of sample types.
    Purification
    Protein A Chromatography
    Immunogen
    This antibody was raised against 6-Methyladenosine conjugated to BSA.
    Clone
    17-3-4-1
    Isotype
    IgG1 kappa
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    N6-Methyladenosine
    Alternative Name
    N6-Methyladenosine (m6A)
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