H2AFJ antibody (AA 122-129)

Catalog No. ABIN6971761

Product Details anti-H2AFJ Antibody

Target: H2AFJ (H2A Histone Family, Member J (H2AFJ))

Binding Specificity: AA 122-129

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H2AFJ antibody is un-conjugated

Application: Western Blotting (WB), Dot Blot (DB)

Characteristics: Histone H2A is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points, and is responsible for establishing higher-order chromatin structure. Histone H2A.J is a histone H2A variant, a protein similar to canonical H2A but with different molecular identity and unique functions. Histone H2A.J, which is found only in mammals, is shown to be associated with senescence, accumulating in senescent fibroblasts and promoting expression of inflammatory genes. Therefore, H2A.J may contribute to chronic inflammation and age-related diseases. Histone H2A.J antibody (pAb) was raised in a Rabbit host. It has been validated for use in Dot blot and Western blot, it has been shown to react with Human and Mouse samples.

Purification: Affinity Purified

Immunogen: This antibody was raised against a peptide comprising amino acids 122-129 of human Histone H2A.J.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for H2AFJ

Target: H2AFJ (H2A Histone Family, Member J (H2AFJ))

Alternative Name: Histone H2A.J (H2AFJ Products)

Synonyms: H2AJ antibody, H2a/j antibody, H2A-IX antibody, H2AFJ antibody, E130307C13 antibody, h2afj antibody, H2A histone family member J antibody, H2A histone family, member J antibody, histone H2A.J antibody, H2A histone family member J L homeolog antibody, H2AFJ antibody, H2afj antibody, LOC103690002 antibody, h2afj.L antibody

NCBI Accession: NP_808760