GLYR1 antibody (C-Term)

Catalog No. ABIN6971688

Product Details anti-GLYR1 Antibody

Target: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLYR1 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: GLYR1 / NDF (nucleosome-destabilizing factor) that is recruited to gene bodies during transcriptional activation and facilitates Pol II transcription through nucleosomes, where it is proposed to ""unzip"" chromatin during transcription, pushing the polymerase past pause points. It was discovered as a factor that allows p300 to acetylate Histone H3K56, which is normally an inaccessible residue for this modification. GLYR1 is shown to associate with a subset of highly transcribed genes tending to have longer mRNAs rather than shorter, and is also at a significant subset of loci containing the Histone H3K36me3. GLYR1 is expressed at high levels in most tissue types, including stem cells, and has been found to be overexpressed in breast cancer. GLYR1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogen: This antibody was raised against a peptide within the C-terminal region of human GLYR1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in 70 mM Tris, 105 mM NaCl, 0.07 mM EDTA, 31 mM glycine, 30 % glycerol, and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for GLYR1

Target: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Alternative Name: GLYR1 (GLYR1 Products)

Synonyms: N-PAC antibody, BM045 antibody, HIBDL antibody, NP60 antibody, 2810419J22Rik antibody, 3930401K13Rik antibody, AW545332 antibody, Npac antibody, 3930401k13rik antibody, N-pac antibody, RGD1309459 antibody, glyoxylate reductase 1 homolog antibody, glyoxylate reductase 1 homolog (Arabidopsis) antibody, GLYR1 antibody, Glyr1 antibody

Molecular Weight: 65 kDa

NCBI Accession: NP_115958