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Cullin 4B antibody (N-Term)

CUL4B Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6971562
  • Target See all Cullin 4B (CUL4B) Antibodies
    Cullin 4B (CUL4B)
    Binding Specificity
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 60
    • 22
    • 21
    • 9
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 55
    • 5
    Rabbit
    Clonality
    • 57
    • 3
    Polyclonal
    Conjugate
    • 32
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Cullin 4B antibody is un-conjugated
    Application
    • 40
    • 19
    • 9
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Characteristics
    CUL4B (Cullin 4B) is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, Histone H2A, Histone H3 and Histone H4 in response to radiation-induced DNA damage and may act as a transcriptional corepressor by ubiquitination of Histone H2AK119 and recruiting PRC2 complexes. CUL4B antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
    Purification
    Affinity Purified
    Immunogen
    This antibody was raised against a peptide within the N-terminal region of human CUL4B.
    Isotype
    IgG
    Top Product
    Discover our top product CUL4B Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target
    Cullin 4B (CUL4B)
    Alternative Name
    CUL4B (CUL4B Products)
    Synonyms
    MRXHF2 antibody, MRXS15 antibody, MRXSC antibody, SFM2 antibody, 2700050M05Rik antibody, AA409770 antibody, CUL-4B antibody, mKIAA0695 antibody, RGD1564494 antibody, im:7140950 antibody, im:7150765 antibody, MGC115611 antibody, Tb03.1J15.620 antibody, sfm2 antibody, mrxsc antibody, mrxhf2 antibody, cullin 4B antibody, cullin 4B S homeolog antibody, CUL4B antibody, Cul4b antibody, cul4b antibody, cul4b.S antibody, Tb927.3.1290 antibody
    Molecular Weight
    110 kDa
    NCBI Accession
    NP_003579
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