CoREST antibody (C-Term)

Catalog No. ABIN6971547

Product Details anti-CoREST Antibody

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CoREST antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: CoREST (REST corepressor 1, RCOR1) is a corepressor protein recruited by the REST, a neuronal gene-specific transcriptional repressor, to help repress neuron specific gene expression in non-neuronal cell lineages. CoREST is an essential component of the BHC repressor complex that also contains HDAC1, HDAC2, HMG20B/BRAF35, LSD1 (a lysine-4 specific histone demethylase) and PHF21A/BHC80. The Herpes Simplex virus ICP0 protein blocks the repression of viral genes by disrupting the interaction between CoREST and HDAC1/2. CoREST antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogen: This CoREST antibody was raised against a synthetic peptide derived from the C-terminal region of human CoREST.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details for CoREST

Target: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Alternative Name: CoREST (RCOR1 Products)

Synonyms: COREST antibody, RCOR antibody, 5730409O11 antibody, 6720480E22Rik antibody, AU042633 antibody, D12Wsu95e antibody, mKIAA0071 antibody, rcor1 antibody, xcoREST antibody, RCOR1 antibody, im:6904264 antibody, si:dkey-46n18.7 antibody, zgc:158607 antibody, RGD1305743 antibody, REST corepressor 1 antibody, REST corepressor 1 L homeolog antibody, RCOR1 antibody, Rcor1 antibody, rcor1.L antibody, rcor1 antibody

Molecular Weight: 66 kDa

NCBI Accession: NP_055971

Pathways: Regulation of Hormone Metabolic Process, Chromatin Binding