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IL-12/IL-23 p40 antibody

Reactivity: Mouse Neut Host: Rat Monoclonal C17-8 unconjugated
Catalog No. ABIN6964022
  • Target See all IL-12/IL-23 p40 products
    IL-12/IL-23 p40
    Reactivity
    • 11
    • 3
    • 1
    Mouse
    Host
    • 11
    • 3
    Rat
    Clonality
    • 14
    Monoclonal
    Conjugate
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-12/IL-23 p40 antibody is un-conjugated
    Application
    • 9
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Neutralization (Neut)
    Specificity
    Native and recombinant p40 subunit of mouse IL-12 and IL-23. The antibody recognizes p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40+p35) and IL-23 heterodimer (p40+p19).
    Purification
    Purified from in vitro cultures by protein G affinity chromatography.
    Immunogen
    Recombinant mouse IL-12 p70
    Clone
    C17-8
    Isotype
    IgG2a
  • Application Notes
    Neutralization of mouse IL-12 and IL-23 bioactivity. It is recommended to establish the optimal antibody concentration for the assay system used. The antibody is also suitable for immunoassays.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    supplied at 1 mg/mL in PBS free of preservatives
    Preservative
    Without preservative
    Storage
    4 °C,-20 °C
    Storage Comment
    Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.
    Expiry Date
    18 months
  • Prabhakara, Harro, Leid, Keegan, Prior, Shirtliff: "Suppression of the inflammatory immune response prevents the development of chronic biofilm infection due to methicillin-resistant Staphylococcus aureus." in: Infection and immunity, Vol. 79, Issue 12, pp. 5010-8, (2012) (PubMed).

    Lee, Hoeman, Hardaway, Guloglu, Ellis, Jain, Divekar, Tartar, Haymaker, Zaghouani: "Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity." in: The Journal of experimental medicine, Vol. 205, Issue 10, pp. 2269-80, (2008) (PubMed).

    Chackerian, Chen, Brodie, Mattson, McClanahan, Kastelein, Bowman: "Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection." in: Infection and immunity, Vol. 74, Issue 11, pp. 6092-9, (2006) (PubMed).

  • Target
    IL-12/IL-23 p40
    Alternative Name
    IL12/23 (p40) (IL-12/IL-23 p40 Products)
    Gene ID
    16160
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