IL-21 antibody

Catalog No. ABIN6963915

Product Details anti-IL-21 Antibody

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Reactivity: Human, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-21 antibody is un-conjugated

Application: ELISA, ELISpot

Specificity: Native and recombinant IL-21

Cross-Reactivity (Details): The monoclonal antibody cross-reacts with IL-21 from non-human primates.

Purification: Purified from in vitro cultures by protein G affinity chromatography.

Immunogen: Recombinant human IL-21

Clone: MT216G

Isotype: IgG1

Application Details

Application Notes: For quantification of IL-21 in solution e.g. cell culture supernatants using ELISA and for enumeration of IL-21 producing cells using ELISpot. MT216G is recommended as coating mAb in combination with detection mAb MT21.3m .

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Expiry Date: 18 months

References for anti-IL-21 antibody (ABIN6963915)

Yamamoto, Kitawaki, Sugimoto, Fujita, Kawase, Takaori-Kondo, Kadowaki: "Anti-inflammatory modulation of human myeloid-derived dendritic cell subsets by lenalidomide." in: Immunology letters, Vol. 211, pp. 41-48, (2020) (PubMed).

Laestadius, Ingelman-Sundberg, Myrberg, Verme, Sundberg, Schweiger, Saghafian-Hedengren, Nilsson: "Altered proportions of circulating CXCR5+ helper T cells do not dampen influenza vaccine responses in children with rheumatic disease." in: Vaccine, Vol. 37, Issue 28, pp. 3685-3693, (2020) (PubMed).

Zhou, Tong, Guan, Li, Feng, Zhou, Zhang: "Circulating follicular helper T cells presented distinctively different responses toward bacterial antigens in primary biliary cholangitis." in: International immunopharmacology, Vol. 51, pp. 76-81, (2018) (PubMed).

Hennerici, Pollmann, Schmidt, Seipelt, Tackenberg, Möbs, Ghoreschi, Hertl, Eming: "Increased Frequency of T Follicular Helper Cells and Elevated Interleukin-27 Plasma Levels in Patients with Pemphigus." in: PLoS ONE, Vol. 11, Issue 2, pp. e0148919, (2016) (PubMed).

Target Details for IL-21

Target: IL-21 (IL21) (Interleukin 21 (IL21))

Alternative Name: IL21 (IL21 Products)

Synonyms: IL-21 antibody, Za11 antibody, interleukin 21 antibody, IL21 antibody, Il21 antibody

Gene ID: 59067

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response