IL12 antibody (Biotin)

Catalog No. ABIN6963866

Product Details anti-IL12 Antibody (Biotin)

Target: IL12 (Interleukin 12 (IL12))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL12 antibody is conjugated to Biotin

Application: ELISA, ELISpot

Specificity: Native and recombinant mouse IL-12 p70. The antibody recognizes the p35 subunit of IL-12 p70 heterodimer (p40 + p35).

Purification: Biotinylated through reaction with a N-hydroxysuccinimide ester of biotin.,Purified from in vitro cultures by protein G affinity chromatography.

Sterility: 0.2 μm filtered

Immunogen: Recombinant mouse IL-12

Clone: IL12-IV

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: supplied at 1 mg/mL in PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Expiry Date: 18 months

References for anti-IL12 antibody (Biotin) (ABIN6963866)

Zheng, Chen, Qu, Chen, Wang, Zhang, Chen: "Influenza H7N9 LAH-HBc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses." in: Vaccine, Vol. 34, Issue 51, pp. 6464-6471, (2017) (PubMed).

Yazdi, Varastehmoradi, Faghfuri, Mavandadnejad, Mahdavi, Shahverdi: "Adjuvant Effect of Biogenic Selenium Nanoparticles Improves the Immune Responses and Survival of Mice Receiving 4T1 Cell Antigens as Vaccine in Breast Cancer Murine Model." in: Journal of nanoscience and nanotechnology, Vol. 15, Issue 12, pp. 10165-72, (2017) (PubMed).

Breyner, Michon, de Sousa, Vilas Boas, Chain, Azevedo, Langella, Chatel: "Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii Shows a Protective Effect on DNBS and DSS-Induced Colitis Model in Mice through Inhibition of NF-κB Pathway." in: Frontiers in microbiology, Vol. 8, pp. 114, (2017) (PubMed).

Tadepalli, Singh, Balakrishna, Murali, Batra: "Immunogenicity and protective efficacy of Brucella abortus recombinant protein cocktail (rOmp19+rP39) against B. abortus 544 and B. melitensis 16M infection in murine model." in: Molecular immunology, Vol. 71, pp. 34-41, (2016) (PubMed).

Zhang, Wang, Liu, Chen, Li, Yang, An, Ma, Pan, Ma: "Comparison of PLA microparticles and alum as adjuvants for H5N1 influenza split vaccine: adjuvanticity evaluation and preliminary action mode analysis." in: Pharmaceutical research, Vol. 31, Issue 4, pp. 1015-31, (2014) (PubMed).

Target Details for IL12

Target: IL12 (Interleukin 12 (IL12))

Alternative Name: IL12 (p70) (IL12 Products)

Synonyms: CLMF antibody, CLMF2 antibody, IL-12B antibody, NKSF antibody, NKSF2 antibody, p40 antibody, Il-12b antibody, Il12p40 antibody, Il-12p40 antibody, Il12 antibody, IL-12p40 antibody, IL-12 antibody, LOC100217488 antibody, IL-12p35 antibody, Il-12a antibody, Ll12a antibody, p35 antibody, IL12p40 antibody, IL12B antibody, IL-12 p35 antibody, interleukin 12B antibody, interleukin 12A antibody, interleukin 12b antibody, interleukin 12a antibody, Interleukin 12 level antibody, IL12B antibody, IL12A antibody, Il12b antibody, Il12a antibody, IL12 antibody, il12a antibody

Gene ID: 16159, 16160

Pathways: JAK-STAT Signaling, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome