KLRG1 antibody
-
- Target See all KLRG1 Antibodies
- KLRG1 (Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1))
-
Reactivity
- Mouse
-
Host
-
Golden Syrian Hamster
-
Clonality
- Monoclonal
-
Conjugate
- This KLRG1 antibody is un-conjugated
-
Application
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Purification
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- Clone
- 2F1
- Isotype
- IgG
- Top Product
- Discover our top product KLRG1 Primary Antibody
-
-
- Application Notes
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Comment
-
0.5 mg/mL
- Restrictions
- For Research Use only
-
- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, pH 7.2
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- 2-8°C
- Expiry Date
- 12 months
-
- Target
- KLRG1 (Killer Cell Lectin-Like Receptor Subfamily G, Member 1 (KLRG1))
- Alternative Name
- KLRG1 (KLRG1 Products)
- Synonyms
- KLRG1 antibody, 2F1-Ag antibody, MAFA antibody, MAFA-L antibody, 2F1 antibody, CLEC15A antibody, MAFA-2F1 antibody, MAFA-LIKE antibody, killer cell lectin like receptor G1 antibody, killer cell lectin-like receptor subfamily G, member 1 antibody, KLRG1 antibody, Klrg1 antibody
- Background
- The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).The 2F1 antibody may be used as a phenotypic marker for KLRG1 in mouse, frequently in combination with Anti-Mouse CD127 antibody (clone A7R34), for identification of effector T cell populations.
- Gene ID
- 50928
- UniProt
- O88713
-