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XDH antibody

XDH Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Monoclonal 2D9 unconjugated
Catalog No. ABIN6945395
  • Target See all XDH Antibodies
    XDH (Xanthine Dehydrogenase (XDH))
    Reactivity
    • 43
    • 20
    • 15
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 50
    • 9
    • 1
    Rabbit
    Clonality
    • 42
    • 18
    Monoclonal
    Conjugate
    • 24
    • 8
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    This XDH antibody is un-conjugated
    Application
    • 38
    • 24
    • 24
    • 11
    • 10
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    Recombinant protein within human Xanthine Oxidase aa 100-300.
    Clone
    2D9
    Isotype
    IgG
    Top Product
    Discover our top product XDH Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    XDH (Xanthine Dehydrogenase (XDH))
    Alternative Name
    Xanthine Oxidase (XDH Products)
    Synonyms
    XO antibody, XOR antibody, Xor antibody, Xox-1 antibody, Xox1 antibody, XDH antibody, im:7146167 antibody, DDBDRAFT_0219626 antibody, DDBDRAFT_0230176 antibody, DDB_0219626 antibody, DDB_0230176 antibody, xanthine dehydrogenase antibody, xanthine dehydrogenase/oxidase antibody, Xanthine dehydrogenase antibody, XDH antibody, Xdh antibody, xdh antibody, LOC576712 antibody, Trebr_1754 antibody
    Background

    Synonyms: Xanthine dehydrogenase/oxidase, Xanthine dehydrogenase, Xanthine oxidase, Xanthine oxidoreductase, XD, XO, XOR, XDH, XDHA

    Background: The process of metabolizing purines to a common molecule known as xanthine is an essential process for the proper shuttling of uric acid. Xanthine oxidase is a flavoprotein enzyme that coordinates molybdenum and utilizes NAD+ as an electron acceptor to catalyze the oxidation of hypoxanthine to xanthine and then to uric acid. The predominant form of this enzyme is xanthine dehydrogenase, which is a homodimer that can be converted to xanthine oxidase by sulfhydryl oxidation or proteolytic modification. Xanthine oxidase is present in species ranging from bacteria to human and is ubiquitously expressed in mammalian tissues. In the oxidase form, this enzyme is coupled to the generation of free radicals. Individuals showing marked elevation of serum xanthine oxidase is suggestive of chronic liver disease and cholestasis, which is a condition defined by hepatic obstruction. Hepatic obstruction causes bile salts, the bile pigment bilirubin, and fats to accumulate in the blood stream instead of being eliminated normally. The clinical consequences of defects in xanthine oxidase range from mild to severe and even contribute to fatal disorders.

    Gene ID
    7498
    UniProt
    P47989
    Pathways
    Positive Regulation of Endopeptidase Activity
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