TP53INP1 antibody

Catalog No. ABIN6945196

Product Details anti-TP53INP1 Antibody

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TP53INP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Full length recombinant protein of human TP53INP1

Clone: 6C1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TP53INP1

Target: TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))

Alternative Name: TP53INP1 (TP53INP1 Products)

Synonyms: cb1036 antibody, wu:fb70a09 antibody, wu:fi13h08 antibody, zgc:158431 antibody, TP53INP1 antibody, 2700057G22Rik antibody, SIP antibody, SIP18 antibody, SIP27 antibody, Stinp antibody, Teap antibody, TP53DINP1 antibody, TP53INP1A antibody, TP53INP1B antibody, p53DINP1 antibody, Trp53inp1 antibody, tumor protein p53 inducible nuclear protein 1 antibody, tumor protein p53 inducible nuclear protein 1 S homeolog antibody, transformation related protein 53 inducible nuclear protein 1 antibody, TP53INP1 antibody, tp53inp1.S antibody, tp53inp1 antibody, Trp53inp1 antibody, Tp53inp1 antibody

Background:

Synonyms: Tumor protein p53-inducible nuclear protein 1, Stress-induced protein, p53-dependent damage-inducible nuclear protein 1, p53DINP1, TP53INP1, P53 DINP1, SIP

Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Gene ID: 94241

UniProt: Q96A56