TET2 antibody

Catalog No. ABIN6945142

Product Details anti-TET2 Antibody

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TET2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Cross-Reactivity: Human, Mouse

Purification: Protein G purified polyclonal antibody in PBS containing 0.05% azide

Immunogen: Monoclonal antibody raised in mouse against a recombinant protein containing the N-terminal 300 amino acids of human TET2 (tet oncogene family member 2).

Clone: 6A1

Isotype: IgG1

Application Details

Application Notes: WB 1:300-5000
IP(1-2 μg)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: PBS with 0.05 % sodium azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Alternative Name: TET2 (TET2 Products)

Synonyms: KIAA1546 antibody, MDS antibody, Ayu17-449 antibody, E130014J05Rik antibody, mKIAA1546 antibody, RGD1311625 antibody, tet methylcytosine dioxygenase 2 antibody, TET2 antibody, Tet2 antibody

Background:

Synonyms: Methylcytosine dioxygenase TET2, TET2, KIAA1546

Background: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.

Gene ID: 54790

UniProt: Q6N021

Pathways: Warburg Effect