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SRP54 antibody

SRP54 Reactivity: Human, Mouse, Rat WB, IP, IHC (p), FACS Host: Rabbit Monoclonal 1A4 unconjugated
Catalog No. ABIN6945061
  • Target See all SRP54 Antibodies
    SRP54 (Signal Recognition Particle 54kDa (SRP54))
    Reactivity
    • 46
    • 18
    • 17
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 43
    • 2
    • 1
    Rabbit
    Clonality
    • 43
    • 3
    Monoclonal
    Conjugate
    • 22
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SRP54 antibody is un-conjugated
    Application
    • 30
    • 28
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    Recombinant protein within human SRP54 aa 1-200.
    Clone
    1A4
    Isotype
    IgG
    Top Product
    Discover our top product SRP54 Primary Antibody
  • Application Notes
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IP(1-2 μg)
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    SRP54 (Signal Recognition Particle 54kDa (SRP54))
    Alternative Name
    SRP54 (SRP54 Products)
    Synonyms
    Srp54k antibody, zgc:55842 antibody, zgc:85713 antibody, SRP54 antibody, signal recognition particle 54 antibody, signal recognition particle protein antibody, signal recognition particle subunit Srp54 antibody, signal recognition particle antibody, family with sequence similarity 177 member A1 antibody, signal recognition particle 54kDa S homeolog antibody, signal recognition particle 54kDa antibody, SRP54 antibody, srp54 antibody, SSO_RS04840 antibody, MA_RS23935 antibody, AF_RS03170 antibody, PAB_RS02540 antibody, MSP_RS07670 antibody, RCI_RS04175 antibody, TGAM_RS09885 antibody, MTBMA_RS08340 antibody, FAM177A1 antibody, srp54.S antibody, Srp54 antibody
    Background

    Synonyms: Signal recognition particle 54 kDa protein, SRP54

    Background: SRP54, a component of the signal recognition particle (SRP), recognizes the signal peptide of secretory proteins and interacts with the signal recognition particle receptor to target the ribosome and the associated nascent chain to the endoplasmic reticulum. By functional analysis showed that SRP54 binds to SRP RNA via the M-domain, but only in the presence of RNA-bound SRP19, and that it associates with the signal peptide of nascent polypeptide chains. RNA interaction requires the presence of a loop in the C-terminal M-domain. Signal peptide recognition most likely involves methionine-rich loops. During signal peptide recognition, SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts the signal recognition particle receptor, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to dock with the ribosome, leading to insertion of the signal peptide into the translocation channel.

    Gene ID
    6729
    UniProt
    P61011
    Pathways
    SARS-CoV-2 Protein Interactome
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