SPCS2 antibody (AA 2-100) (HRP)

Catalog No. ABIN6945026

Product Details anti-SPCS2 Antibody (HRP)

Target: SPCS2 (Signal Peptidase Complex Subunit 2 Homolog (SPCS2))

Binding Specificity: AA 2-100

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPCS2 antibody is conjugated to HRP

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SPCS2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SPCS2

Target: SPCS2 (Signal Peptidase Complex Subunit 2 Homolog (SPCS2))

Alternative Name: SPCS2 (SPCS2 Products)

Synonyms: RGD1311253 antibody, 5730406I15Rik antibody, AA408713 antibody, mKIAA0102 antibody, SPC25 antibody, signal peptidase complex subunit 2 antibody, signal peptidase complex subunit 2 homolog (S. cerevisiae) antibody, Spcs2 antibody, SPCS2 antibody

Background:

Synonyms: Microsomal signal peptidase 25 kDa subunit, Signal peptidase complex subunit 2, Signal peptidase complex subunit 2 homolog (S. cerevisiae), SPase 25 kDa subunit, SPCS2, SPCS2_HUMAN.

Background: SPCS2 is a 226 amino acid multi-pass membrane protein that localizes to both the microsome and the endoplasmic reticulum (ER), and belongs to the SPCS (signal peptidase complex subunit) family. Existing as a component of the microsomal signal peptidase complex which consists of five members, SPCS2 removes signal peptides from nascent proteins as they are translocated into the lumen of the ER. The gene encoding SPCS2 is located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4 % of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

Gene ID: 9789

UniProt: Q15005

Pathways: Peptide Hormone Metabolism