RPE65 antibody
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- Target See all RPE65 Antibodies
- RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
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Reactivity
- Human, Rat, Mouse
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This RPE65 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- Human RPE65 aa 450 to the C-terminus
- Clone
- 2C1
- Isotype
- IgG
- Top Product
- Discover our top product RPE65 Primary Antibody
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- Application Notes
- WB 1:300-5000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
- Alternative Name
- RPE65 (RPE65 Products)
- Synonyms
- LCA2 antibody, RP20 antibody, mRPE65 antibody, rd12 antibody, sRPE65 antibody, 65kDa antibody, A930029L06Rik antibody, Mord1 antibody, DRPE65 antibody, RPE65 antibody, anon-WO0148162.1 antibody, anon-WO0148163.1 antibody, beta-diox antibody, DmelCG9347 antibody, CG9347 antibody, MGC52887 antibody, MGC154296 antibody, MGC85437 antibody, rpe65 antibody, RPE56c antibody, si:ch211-198n5.12 antibody, 13cIMH antibody, RPE56b antibody, rpepb antibody, si:ch211-198n5.5 antibody, wu:fc74c09 antibody, zgc:110538 antibody, RPE56a antibody, rpepa antibody, zgc:73213 antibody, RPE65, retinoid isomerohydrolase antibody, retinal pigment epithelium 65 antibody, neither inactivation nor afterpotential B antibody, retinal pigment epithelium-specific protein 65kDa S homeolog antibody, retinal pigment epithelium-specific protein 65kDa L homeolog antibody, RPE65 homolog antibody, retinal pigment epithelium-specific protein 65kDa antibody, retinal pigment epithelium-specific protein 65c antibody, retinal pigment epithelium-specific protein 65b antibody, retinal pigment epithelium-specific protein 65a antibody, RPE65 antibody, Rpe65 antibody, ninaB antibody, rpe65.S antibody, rpe65.L antibody, rpe65 antibody, rpe65c antibody, rpe65b antibody, rpe65a antibody
- Background
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Synonyms: Retinoid isomerohydrolase, All-trans-retinyl-palmitate hydrolase, Retinal pigment epithelium-specific 65 kDa protein, Retinol isomerase, RPE65
Background: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity).
- Gene ID
- 6121
- UniProt
- Q16518
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