PFKFB3 antibody (AA 421-520) (Biotin)
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- Target See all PFKFB3 Antibodies
- PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))
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Binding Specificity
- AA 421-520
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Reactivity
- Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PFKFB3 antibody is conjugated to Biotin
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Mouse, Rat
- Predicted Reactivity
- Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human PFKFB3
- Isotype
- IgG
- Top Product
- Discover our top product PFKFB3 Primary Antibody
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- Application Notes
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IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- PFKFB3 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 3 (PFKFB3))
- Alternative Name
- PFKFB3/PFK2 (PFKFB3 Products)
- Synonyms
- IPFK2 antibody, PFK2 antibody, E330010H22Rik antibody, iPFK-2 antibody, uPFK-2 antibody, PFKFB3 antibody, zgc:73257 antibody, wu:fc31e01 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 antibody, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 S homeolog antibody, PFKFB3 antibody, Pfkfb3 antibody, pfkfb3.S antibody, pfkfb3 antibody, PTRG_09894 antibody, Tsp_06710 antibody
- Background
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Synonyms: 6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase, 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3, 6-bisphosphatase, 6-P2ase 3, 6-P2ASE brain/placenta-type isozyme, 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme, 6PF 2-K/Fru 2,6 P2ase 3, 6PF-2-K/Fru-2, F263_HUMAN, fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase, Fructose-2, Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase, iPFK 2, iPFK-2, IPFK2, PFK/FBPase 3, PFK2, PFKFB3, Renal carcinoma antigen NY REN 56, Renal carcinoma antigen NY-REN-56, uPFK 2.
Background: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
- Gene ID
- 5209
- UniProt
- Q16875
- Pathways
- AMPK Signaling, Regulation of Carbohydrate Metabolic Process
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