PD-L1 antibody
-
- Target See all PD-L1 Antibodies
- PD-L1 (CD274 (PD-L1))
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Monoclonal
-
Conjugate
- This PD-L1 antibody is un-conjugated
-
Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Cross-Reactivity
- Human
- Purification
- Purified by Protein A.
- Immunogen
- Recombinant human PD-L1 extracellular domain
- Clone
- 6C8
- Isotype
- IgG
- Top Product
- Discover our top product PD-L1 Primary Antibody
-
-
- Application Notes
-
WB 1:300-5000
FCM 1:20-100 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
-
- Target
- PD-L1 (CD274 (PD-L1))
- Alternative Name
- PD-L1 (PD-L1 Products)
- Synonyms
- B7-H antibody, B7H1 antibody, PD-L1 antibody, PDCD1L1 antibody, PDCD1LG1 antibody, PDL1 antibody, A530045L16Rik antibody, B7h1 antibody, Pdcd1l1 antibody, Pdcd1lg1 antibody, Pdl1 antibody, RGD1566211 antibody, CD274 molecule antibody, CD274 antigen antibody, programmed cell death 1 ligand 2 antibody, CD274 antibody, Cd274 antibody, PDCD1LG2 antibody
- Background
-
Synonyms: Programmed cell death 1 ligand 1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, Programmed death ligand 1
Background: Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
- Gene ID
- 29126
- UniProt
- Q9NZQ7
- Pathways
- Cancer Immune Checkpoints
-