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MUC4 antibody

MUC4 Reactivity: Human, Rat WB, IHC (p), FACS Host: Rabbit Monoclonal 3A1 unconjugated
Catalog No. ABIN6944168
  • Target See all MUC4 Antibodies
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Reactivity
    • 37
    • 12
    • 3
    Human, Rat
    Host
    • 29
    • 9
    Rabbit
    Clonality
    • 22
    • 16
    Monoclonal
    Conjugate
    • 22
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This MUC4 antibody is un-conjugated
    Application
    • 20
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Cross-Reactivity
    Human, Rat
    Purification
    Purified by Protein A.
    Immunogen
    C terminal Human MUC4
    Clone
    3A1
    Isotype
    IgG
    Top Product
    Discover our top product MUC4 Primary Antibody
  • Application Notes
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    MUC4 (Mucin 4, Cell Surface Associated (MUC4))
    Alternative Name
    MUC4 (MUC4 Products)
    Synonyms
    4933405I11Rik antibody, Asgp antibody, ASGP antibody, HSA276359 antibody, MUC-4 antibody, ASGP-1 antibody, Psmc antibody, mucin 4 antibody, mucin 4, cell surface associated antibody, Muc4 antibody, MUC4 antibody
    Background

    Synonyms: Mucin-4, Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin-4 alpha chain, Ascites sialoglycoprotein 1, Mucin-4 beta chain, Ascites sialoglycoprotein 2, MUC-4, ASGP, ASGP-1, ASGP-2, MUC4

    Background: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

    Gene ID
    4585
    UniProt
    Q99102
    Pathways
    Regulation of Leukocyte Mediated Immunity
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