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KDELR1 antibody

KDELR1 Reactivity: Human, Mouse, Rat WB, FACS, IF (cc), IF (p), IHC (p) Host: Rabbit Monoclonal 3A6 unconjugated
Catalog No. ABIN6943880
  • Target See all KDELR1 Antibodies
    KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))
    Reactivity
    • 19
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 18
    • 2
    Rabbit
    Clonality
    • 18
    • 2
    Monoclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    This KDELR1 antibody is un-conjugated
    Application
    • 20
    • 13
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    Synthetic peptide corresponding to C-terminal human KDEL
    Clone
    3A6
    Isotype
    IgG
    Top Product
    Discover our top product KDELR1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    KDELR1 (KDEL (Lys-Asp-Glu-Leu) Endoplasmic Reticulum Protein Retention Receptor 1 (KDELR1))
    Alternative Name
    KDELR1 (KDELR1 Products)
    Synonyms
    ERD2 antibody, ERD2.1 antibody, HDEL antibody, PM23 antibody, 8030486F04Rik antibody, AW215843 antibody, Erd2.1 antibody, KDEL endoplasmic reticulum protein retention receptor 1 antibody, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 antibody, KDELR1 antibody, Kdelr1 antibody
    Background

    Synonyms: ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, Putative MAPK-activating protein PM23, KDEL receptor 1, KDELR1, ERD2.1

    Background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR1 was the first member of the family to be identified, and it is structurally and functionally similar to the yeast ERD2. KDELR1 is required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi.

    Gene ID
    10945
    UniProt
    P24390
    Pathways
    Maintenance of Protein Location
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