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IQSEC1 antibody (AA 451-550) (Biotin)

IQSEC1 Reactivity: Mouse WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin
Catalog No. ABIN6943529
  • Target See all IQSEC1 Antibodies
    IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))
    Binding Specificity
    • 14
    • 3
    • 2
    • 1
    AA 451-550
    Reactivity
    • 18
    • 5
    • 4
    Mouse
    Host
    • 19
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IQSEC1 antibody is conjugated to Biotin
    Application
    • 19
    • 13
    • 13
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Dog,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GEP100
    Isotype
    IgG
    Top Product
    Discover our top product IQSEC1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for 12 months.
    Expiry Date
    12 months
  • Target
    IQSEC1 (IQ Motif and Sec7 Domain 1 (IQSEC1))
    Alternative Name
    GEP100/IQSEC1 (IQSEC1 Products)
    Synonyms
    ARF-GEP100 antibody, ARFGEP100 antibody, BRAG2 antibody, GEP100 antibody, AW561907 antibody, BC026481 antibody, D6Ertd349e antibody, cI-43 antibody, mKIAA0763 antibody, IQ motif and Sec7 domain 1 antibody, IQSEC1 antibody, Iqsec1 antibody
    Background

    Synonyms: ADP-ribosylation factors guanine nucleotide-exchange protein 100, ADP-ribosylation factors guanine nucleotide-exchange protein 2, ARF GEP100, ARFGEP100, BRAG2, Brefeldin A resistant ARF GEF2, Brefeldin-resistant Arf-GEF 2 protein, GEP100, IQ motif and Sec7 domain 1, IQ motif and SEC7 domain-containing protein 1, IQEC1_HUMAN, Iqsec1, Kiaa0763.

    Background: The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin 1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells.

    Gene ID
    9922
    UniProt
    Q6DN90
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