DENND1A antibody (AA 42-140) (Biotin)

Catalog No. ABIN6942845

Product Details anti-DENND1A Antibody (Biotin)

Target: DENND1A (DENN/MADD Domain Containing 1A (DENND1A))

Binding Specificity: AA 42-140

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DENND1A antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DENND1A

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DENND1A

Target: DENND1A (DENN/MADD Domain Containing 1A (DENND1A))

Alternative Name: DENND1A (DENND1A Products)

Synonyms: RGD1307927 antibody, FAM31A antibody, KIAA1608 antibody, RP11-230L22.3 antibody, 6030446I19Rik antibody, connecdenn antibody, fam31a antibody, DENN domain containing 1A antibody, DENN/MADD domain containing 1A antibody, DENN domain-containing protein 1A antibody, DENN domain containing 1A S homeolog antibody, Dennd1a antibody, DENND1A antibody, dennd1a antibody, LOC100512328 antibody, dennd1a.S antibody

Background:

Synonyms: Connecdenn 1, Connecdenn, DEN1A_HUMAN, DENN domain-containing protein 1A, DENN/MADD domain containing 1A, dennd1a, FAM31A, FLJ21129, FLJ38464, KIAA1608, OTTHUMP00000022090, Protein FAM31A, RP11 230L22.3.

Background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2, see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

Gene ID: 57706

UniProt: Q8TEH3