CTU2 antibody (AA 301-400) (HRP)

Catalog No. ABIN6942721

Product Details anti-CTU2 Antibody (HRP)

Target: CTU2 (Cytosolic Thiouridylase Subunit 2 (CTU2))

Binding Specificity: AA 301-400

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTU2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTU2/C16orf84

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CTU2

Target: CTU2 (Cytosolic Thiouridylase Subunit 2 (CTU2))

Alternative Name: CTU2 (CTU2 Products)

Synonyms: C16orf84 antibody, NCS2 antibody, UPF0432 antibody, Ncs2 antibody, 2310061F22Rik antibody, cytosolic thiouridylase subunit 2 antibody, CTU2 antibody, Ctu2 antibody

Background:

Synonyms: C16orf84, ctu2, CTU2_HUMAN, Cytoplasmic tRNA 2-thiolation protein 2, cytosolic thiouridylase subunit 2 homolog (S. pombe), NCS2, PF0432.

Background: CTU2 is a 515 amino acid cytoplasmic protein that plays a role in the 2-thiolation of mcm(5)S(2)U at wobble positions of tRNA. CTU2 forms a complex with CTU1 and Urm1, and may also form a separate heterodimer with CTU1 to ligate sulfur from thiocarboxylated Urm1 onto tRNA. Existing as three alternatively spliced isoforms, the gene encoding CTU2 maps to human chromosome 16q24.3. Chromosome 16 encodes over 900 genes and comprises nearly 3 % of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Gene ID: 348180

UniProt: Q2VPK5