CEP290 antibody (AA 131-230) (AbBy Fluor® 647)

Catalog No. ABIN6942535

Product Details anti-CEP290 Antibody (AbBy Fluor® 647)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Binding Specificity: AA 131-230

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is conjugated to AbBy Fluor® 647

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CEP290

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290 (CEP290 Products)

Background:

Synonyms: 3H11AG, Bardet-Biedl syndrome 14 protein, BBS14, Cancer/testis antigen 87, CE290_HUMAN, Centrosomal protein 290 kDa, Centrosomal protein of 290 kDa, Cep290, CT87, CTCL tumor antigen se2 2, FLJ13615, FLJ21979, JBTS5, JBTS6, KIAA0373, LCA10, Meckel syndrome, type 4, MKS4, Monoclonal, 3H11 antigen, Nephrocystin 6, Nephrocystin-6, NPHP6, POC3, POC3 centriolar protein homolog, Prostate cancer antigen T21, rd16, SLSN6 1, 2, 5, SLSN6, Tumor antigen se2-2.

Background: This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008

Gene ID: 80184

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase