CBX7 antibody

Catalog No. ABIN6942379

Product Details anti-CBX7 Antibody

Target: CBX7 (Chromobox Homolog 7 (CBX7))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CBX7 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Recombinant protein within human cbx7 aa 1-150

Clone: 5C5

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CBX7

Target: CBX7 (Chromobox Homolog 7 (CBX7))

Alternative Name: CBX7 (CBX7 Products)

Synonyms: 1600014J01Rik antibody, AI851678 antibody, D15Ertd417e antibody, zgc:110152 antibody, chromobox 7 antibody, chromobox homolog 7a antibody, CBX7 antibody, Cbx7 antibody, cbx7a antibody

Background:

Synonyms: Chromobox protein homolog 7, CBX7.

Background: CBX7 (Chromobox protein homolog 7) is a 251 amino acid nuclear protein that contains one N-terminal chromodomain and one C-terminal Pc box. Highly expressed in kidney, brain, heart and skeletal muscle, with weaker expression in peripheral blood leukocytes, CBX7 functions as a component of the chromatin-associated polycomb complex (PcG) and is involved in maintaining the transcriptionally repressed state of target genes. Additionally, CBX7 modifies chromatin and is thought to extend the cellular life span of epithelial cells by repressing p14 ARF expression, while simultaneously repressing telomerase activity. Due to its ability to repress the transcription of cell-cycle-related proteins, CBX7 is thought to play a role in tumorigenesis, specifically in the development of follicular lymphoma and thyroid cancer.

Gene ID: 23492

UniProt: O95931