Tyrosinase-Related Protein 1 antibody (AA 257-377)

Catalog No. ABIN6940830

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Target: Tyrosinase-Related Protein 1 (TYRP1)

Binding Specificity: AA 257-377

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Staining Methods (StM), Coating (Coat)

Specificity: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Purification: Purified by Protein A/G

Immunogen: A recombinant fragment (around aa 257-377) of human TYRP1 protein (exact sequence is proprietary)

Clone: TYRP1-3280

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Human skin or melanoma tissues (IHC).

Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: TYRP1 (TYRP1 Products)

Synonyms: CAS2 antibody, CATB antibody, GP75 antibody, OCA3 antibody, TRP antibody, TRP1 antibody, TYRP antibody, b-PROTEIN antibody, LOC397853 antibody, Trypsin antibody, hm:zeh0659 antibody, tyrp1 antibody, zgc:100893 antibody, B antibody, TYRP1 antibody, tyrp-1 antibody, TRP-1 antibody, Tyrp antibody, b antibody, brown antibody, isa antibody, tyrosinase related protein 1 antibody, protease, serine 1 L homeolog antibody, tyrosinase-related protein 1b antibody, tyrosinase-related protein 1 antibody, tyrosinase-related protein 1 L homeolog antibody, tyrosinase-related protein 1a antibody, TYRP1 antibody, prss1.L antibody, tyrp1b antibody, Tyrp1 antibody, tyrp1.L antibody, tyrp1 antibody, LOC100136490 antibody, tyrp-1 antibody, tyrp1a antibody

Molecular Weight: 75kDa

Gene ID: 7306

UniProt: P17643