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Thyroglobulin antibody

TG Reactivity: Human, Mouse, Rat IHC, FACS, StM Host: Mouse Monoclonal 2H11 unconjugated
Catalog No. ABIN6940704
  • Target See all Thyroglobulin (TG) Antibodies
    Thyroglobulin (TG)
    Reactivity
    • 102
    • 35
    • 35
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 62
    • 39
    • 4
    • 3
    • 1
    • 1
    Mouse
    Clonality
    • 66
    • 41
    Monoclonal
    Conjugate
    • 67
    • 11
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Thyroglobulin antibody is un-conjugated
    Application
    • 42
    • 39
    • 26
    • 25
    • 16
    • 16
    • 11
    • 10
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Flow Cytometry (FACS), Staining Methods (StM)
    Specificity
    MAb 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
    Purification
    Purified by Protein A/G
    Immunogen
    Human thyroid follicular cells
    Clone
    2H11
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product TG Primary Antibody
  • Application Notes

    Positive Control: Thyroid.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL, 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    Thyroglobulin (TG)
    Alternative Name
    Thyroglobulin (Thyroidal Cell Marker) (TG Products)
    Synonyms
    TG antibody, cb717 antibody, AITD3 antibody, TGN antibody, Tgn antibody, cog antibody, thyroglobulin antibody, TG antibody, tg antibody, LOC701526 antibody, LOC701756 antibody, LOC100434297 antibody, Tg antibody
    Molecular Weight
    660kDa (Dimeric Form)
    Gene ID
    7038
    UniProt
    P01266
    Pathways
    Thyroid Hormone Synthesis
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