TAL1 antibody
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- Target See all TAL1 Antibodies
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TAL1 antibody is un-conjugated
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Application
- ELISA, Coating (Coat)
- Purification
- Purified by Protein A/G
- Immunogen
- Recombinant human full-length TAL1 protein
- Clone
- TAL1-2707
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product TAL1 Primary Antibody
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- Application Notes
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Positive Control: A549 xenograft.
Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
- Alternative Name
- TAL1 (TAL1 Products)
- Synonyms
- SCL/tal-1 antibody, Scl antibody, bHLHa17 antibody, tal-1 antibody, SCL antibody, TCL5 antibody, scl antibody, tcl5 antibody, SCL-alpha antibody, SCL-beta antibody, scl/tal1 antibody, zgc:85605 antibody, T cell acute lymphocytic leukemia 1 antibody, TAL bHLH transcription factor 1, erythroid differentiation factor antibody, T-cell acute lymphocytic leukemia 1 S homeolog antibody, T-cell acute lymphocytic leukemia 1 antibody, Tal1 antibody, TAL1 antibody, tal1.S antibody, tal1 antibody
- Background
- Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.
- Molecular Weight
- 42kDa
- Gene ID
- 6886
- UniProt
- P17542
- Pathways
- Stem Cell Maintenance
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