STAR antibody (AA 39-108)

Catalog No. ABIN6940666

Product Details anti-STAR Antibody

Target: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Binding Specificity: AA 39-108

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAR antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa 39-108) of human STAR protein (exact sequence is proprietary)

Clone: STAR-2140

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: K-562 cells. Adrenal or Testicular Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for STAR

Target: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Alternative Name: STAR (STAR Products)

Synonyms: STARD1 antibody, AV363654 antibody, D8Ertd419e antibody, star antibody, LOC100219165 antibody, StARD1 antibody, steroidogenic acute regulatory protein antibody, steroidogenic acute regulatory protein L homeolog antibody, STAR antibody, Star antibody, star antibody, star.L antibody

Background: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone.It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.

Molecular Weight: 30kDa

Gene ID: 6770

UniProt: P49675

Pathways: Metabolism of Steroid Hormones and Vitamin D, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis