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Spectrin beta Chain, Erythrocyte (SPTB) antibody

SPTB Reactivity: Human, Mouse, Rat WB, IF, IHC, Coat, ELISA, StM Host: Mouse Monoclonal RG-26 unconjugated
Catalog No. ABIN6940649
  • Target See all Spectrin beta Chain, Erythrocyte (SPTB) Antibodies
    Spectrin beta Chain, Erythrocyte (SPTB)
    Reactivity
    Human, Mouse, Rat
    Host
    • 7
    • 4
    Mouse
    Clonality
    • 7
    • 4
    Monoclonal
    Conjugate
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Un-conjugated
    Application
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Coating (Coat), ELISA, Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogen
    Red cell membranes
    Clone
    RG-26
    Isotype
    IgG2a kappa
  • Application Notes

    Positive Control: Jurkat whole cell lysate (WB). Human colon carcinoma tissue (IHC).

    Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), ,Immunofluorescence (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    Spectrin beta Chain, Erythrocyte (SPTB)
    Alternative Name
    SPTB (SPTB Products)
    Synonyms
    AI842465 antibody, D330027P03Rik antibody, Gm1301 antibody, Spnb-1 antibody, Spnb1 antibody, ja antibody, jaundiced antibody, mKIAA4219 antibody, EL3 antibody, HS2 antibody, HSPTB1 antibody, SPH2 antibody, spectrin beta, erythrocytic antibody, spectrin, beta, erythrocytic antibody, SPTB antibody, Sptb antibody
    Background
    Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.
    Molecular Weight
    246kDa
    Gene ID
    6710
    UniProt
    O15020
    Pathways
    Regulation of Actin Filament Polymerization
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