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PPP3R1 antibody

PPP3R1 Reactivity: Human, Xenopus laevis WB, ELISA, IHC, StM, Coat Host: Mouse Monoclonal BE2-1 unconjugated
Catalog No. ABIN6940383
  • Target See all PPP3R1 Antibodies
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Reactivity
    • 28
    • 14
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Xenopus laevis
    Host
    • 22
    • 6
    Mouse
    Clonality
    • 22
    • 6
    Monoclonal
    Conjugate
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP3R1 antibody is un-conjugated
    Application
    • 14
    • 11
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Staining Methods (StM), Coating (Coat)
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human Calcineurin B protein
    Clone
    BE2-1
    Isotype
    IgG2a kappa
    Top Product
    Discover our top product PPP3R1 Primary Antibody
  • Application Notes

    Positive Control: HeLa, MCF-7 or A431 cells. Human brain, breast or stomach tissue.

    Known Application: ELISA (For coating, order antibody without BSA), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Alternative Name
    PPP3R1 (PPP3R1 Products)
    Synonyms
    si:ch211-274c22.8 antibody, canb antibody, CALNB1 antibody, CNB antibody, CNB1 antibody, CaNB1 antibody, Cnb1 antibody, MCIP1 antibody, protein phosphatase 3, regulatory subunit B, alpha a antibody, protein phosphatase 3 regulatory subunit B, alpha S homeolog antibody, protein phosphatase 3 regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) antibody, ppp3r1a antibody, ppp3r1.S antibody, PPP3R1 antibody, Ppp3r1 antibody
    Background
    Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
    Molecular Weight
    19kDa
    Gene ID
    5534
    UniProt
    P63098
    Pathways
    RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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