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ANO1 antibody

ANO1 Reactivity: Human IHC, StM Host: Mouse Monoclonal SPM580 unconjugated
Catalog No. ABIN6940371
  • Target See all ANO1 Antibodies
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    Reactivity
    • 129
    • 34
    • 27
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    Human
    Host
    • 85
    • 48
    Mouse
    Clonality
    • 72
    • 61
    Monoclonal
    Conjugate
    • 54
    • 13
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ANO1 antibody is un-conjugated
    Application
    • 60
    • 50
    • 42
    • 36
    • 34
    • 20
    • 16
    • 13
    • 13
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant human DOG-1 protein
    Clone
    SPM580
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product ANO1 Primary Antibody
  • Application Notes

    Positive Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    ANO1 (Anoctamin 1, Calcium Activated Chloride Channel (ANO1))
    Alternative Name
    TMEM16A (ANO1 Products)
    Synonyms
    DOG1 antibody, ORAOV2 antibody, TAOS2 antibody, TMEM16A antibody, Tmem16a antibody, anoctamin 1 antibody, anoctamin 1, calcium activated chloride channel antibody, Ano1 antibody, ANO1 antibody
    Background
    Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4 % vs. 94.7 %.
    Molecular Weight
    ~114kDa
    Gene ID
    55107
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