CD207 antibody (AA 74-213)

Catalog No. ABIN6940244

Product Details anti-CD207 Antibody

Target: CD207 (CD207 Molecule, Langerin (CD207))

Binding Specificity: AA 74-213

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD207 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Coating (Coat)

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment (around aa74-213) of human Langerin protein (exact sequence is proprietary)

Clone: LGRN-1821

Isotype: IgG2a kappa

Application Details

Application Notes:

Positive Control: HeLa or A549 cells (WB).

Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Alternative Name: CD207 (CD207 Products)

Synonyms: CD207 antibody, CLEC4K antibody, RGD1565913 antibody, CD207 molecule antibody, CD207 antigen antibody, CD207 antibody, Cd207 antibody

Background: Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

Molecular Weight: 48kDa

Gene ID: 50489

UniProt: Q9UJ71