MYCN antibody

Catalog No. ABIN6940152

Product Details anti-MYCN Antibody

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYCN antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: Purified by Protein A/G

Immunogen: Recombinant full-length human n-Myc protein.

Clone: NMYC-1

Isotype: IgG2a kappa

Application Details

Application Notes:

Positive Control: 293T whole cell lysates or recombinant Human n-Myc protein.

Known Application: Immunofluorescence (0.5-1 μg/mL), Western Blot (0.5-1.0 μg/mL)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for MYCN

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Alternative Name: MYCN (MYCN Products)

Background: The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

Molecular Weight: 67kDa

Gene ID: 4613

UniProt: P04198