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Recombinant IGHM antibody

IGHM Reactivity: Human IHC, StM Host: Rabbit Monoclonal IGHM-3135R unconjugated Recombinant Antibody
Catalog No. ABIN6939736
  • Target See all IGHM products
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 25
    • 1
    • 1
    Human
    Host
    • 14
    • 11
    Rabbit
    Clonality
    • 16
    • 9
    Monoclonal
    Conjugate
    • 21
    • 1
    • 1
    • 1
    • 1
    This IGHM antibody is un-conjugated
    Application
    • 12
    • 12
    • 11
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificity
    Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant full-length human IGHM protein
    Clone
    IGHM-3135R
    Isotype
    IgG
  • Application Notes

    Positive Control: 293T, Raji or hPBL cells. Tonsil or Spleen.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Alternative Name
    IGHM (IGHM Products)
    Synonyms
    AI326478 antibody, Igh-6 antibody, Igh-M antibody, Igh6 antibody, Igm antibody, muH antibody, ighm1 antibody, wu:fj14a08 antibody, zgc:101769 antibody, AGM1 antibody, MU antibody, VH antibody, immunoglobulin heavy constant mu antibody, Ighm antibody, ighm antibody, IGHM antibody
    Molecular Weight
    50-75kDa
    Gene ID
    3507
    UniProt
    P01871, P20769
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