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Recombinant IGHG4 antibody

IGHG4 Reactivity: Human IHC, ISt, StM Host: Rabbit Monoclonal IGHG4-2042R unconjugated Recombinant Antibody
Catalog No. ABIN6939720
  • Target See all IGHG4 products
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 15
    • 1
    • 1
    Human
    Host
    • 10
    • 5
    Rabbit
    Clonality
    • 10
    • 5
    Monoclonal
    Conjugate
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    This IGHG4 antibody is un-conjugated
    Application
    • 10
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)
    Immunogen
    Recombinant full-length human IGHG4 protein
    Clone
    IGHG4-2042R
    Isotype
    IgG
  • Application Notes

    Positive Control: Tonsil.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
    Alternative Name
    IGHG4 (IGHG4 Products)
    Synonyms
    immunoglobulin heavy constant gamma 4 (G4m marker) antibody, IGHG4 antibody
    Background
    The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lympho-plasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudo-tumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
    Molecular Weight
    150kDa
    Gene ID
    3503
    UniProt
    P01861
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