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HLA-A antibody

HLA-A Reactivity: Human FACS, IF Host: Mouse Monoclonal 108-2C5 unconjugated
Catalog No. ABIN6939619
  • Target See all HLA-A Antibodies
    HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))
    Reactivity
    • 56
    • 15
    • 6
    • 3
    • 1
    Human
    Host
    • 34
    • 29
    • 3
    Mouse
    Clonality
    • 33
    • 33
    Monoclonal
    Conjugate
    • 33
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-A antibody is un-conjugated
    Application
    • 39
    • 29
    • 25
    • 19
    • 18
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (IF)
    Specificity
    HLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This MAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and -Aw33). Its epitope maps between aa65-to-aa80 of the 1 domain of the HLA-A. This MAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the alpha1 domain was demonstrated in the formation of an intralocus HLA-A determinant.
    Immunogen
    Normal human peripheral blood lymphocytes
    Clone
    108-2C5
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product HLA-A Primary Antibody
  • Application Notes

    Positive Control: Raji, THP-1 and Jurkat cells. Tonsil or lymph node.

    Known Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))
    Alternative Name
    HLA-A (HLA-A Products)
    Synonyms
    HLAA antibody, major histocompatibility complex, class I, A antibody, HLA-A antibody
    Molecular Weight
    ~41kDa
    Gene ID
    3105
    UniProt
    P01889, P30443, P30499
    Pathways
    TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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