HLA-ABC antibody
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- Target See all HLA-ABC Antibodies
- HLA-ABC
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Reactivity
- Human, Mouse, Non-Human Primate
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This HLA-ABC antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Specificity
- Reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C). Human MHC class I antigens are expressed constitutively on all nucleated cells lymphocytes such as lymphocytes, thymocytes, granulocytes, and bone marrow cells and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.
- Purification
- Purified by Protein A/G
- Immunogen
- Human peripheral blood leukocytes
- Clone
- 246-B8-E7
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product HLA-ABC Primary Antibody
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- Application Notes
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Positive Control: THP-1 and Jurkat cells. Tonsil or lymph node.
Known Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- HLA-ABC
- Alternative Name
- HLA-A, HLA-B, HLA-C (HLA-ABC Products)
- Synonyms
- HLAA antibody, major histocompatibility complex, class I, A antibody, HLA-A antibody
- Molecular Weight
- ~41kDa
- Gene ID
- 3105, 3106, 3107
- UniProt
- P01889, P30443, P30499
- Pathways
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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