Recombinant GP2 antibody (AA 35-179)
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- Target See all GP2 products
- GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
- Antibody Type
- Recombinant Antibody
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Binding Specificity
- AA 35-179
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Monoclonal
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Conjugate
- This GP2 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), ELISA, Coating (Coat), Staining Methods (StM)
- No Cross-Reactivity
- Mouse (Murine)
- Purification
- Purified by Protein A/G
- Immunogen
- Recombinant human GP2 protein fragment (around aa35-179) (exact sequence is proprietary)
- Clone
- GP2-2569R
- Isotype
- IgG
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- Application Notes
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Positive Control: PANC-1 cells. Pancreas.
Known Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
- Alternative Name
- GP2 (GP2 Products)
- Synonyms
- ZAP75 antibody, 2310037I18Rik antibody, AV060639 antibody, gp80 antibody, glycoprotein 2 antibody, glycoprotein 2 (zymogen granule membrane) antibody, GP2 antibody, Gp2 antibody
- Target Type
- Viral Protein
- Background
- GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
- Molecular Weight
- 59kDa
- Gene ID
- 2813
- UniProt
- P55259
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