NKX2-8 antibody (AA 10-123)

Catalog No. ABIN6939492

Product Details anti-NKX2-8 Antibody

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Binding Specificity: AA 10-123

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NKX2-8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Purified by Protein A/G

Immunogen: Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)

Clone: NKX28-2547

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: Human Liver, Kidney or Thyroid tissue (IHC).

Known Application: Western Blot (0.5 μg-1 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for NKX2-8

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Alternative Name: NKX2-8 (NKX2-8 Products)

Synonyms: NKX2.8 antibody, NKX2H antibody, Nkx2-9 antibody, Nkx-2.9 antibody, Nkx2-8 antibody, Nkx2.9 antibody, tinman antibody, NK2 homeobox 8 antibody, NK2 homeobox 9 antibody, NKX2-8 antibody, Nkx2-9 antibody, Nkx2-8 antibody

Background: The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

Molecular Weight: 26kDa

Gene ID: 26257

UniProt: O15522