TRIM29 antibody (AA 1-200)

Catalog No. ABIN6939434

Product Details anti-TRIM29 Antibody

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Binding Specificity: AA 1-200

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TRIM29 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Coating (Coat), Staining Methods (StM)

Specificity: It recognizes a 66 kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90 % positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment (126 Amino acid residues between aa 1-200) of human TRIM29 protein

Clone: TRIM29-1041

Isotype: IgG2a kappa

Application Details

Application Notes:

Positive Control: Human tonsil or squamous cell carcinoma.

Known Application: ELISA (For coating, order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TRIM29

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Alternative Name: TRIM29 (TRIM29 Products)

Synonyms: ATDC antibody, 1110047J21Rik antibody, 2810431N19Rik antibody, 4732461M22Rik antibody, AI119726 antibody, MGC53484 antibody, TRIM29 antibody, atdc antibody, tripartite motif containing 29 antibody, tripartite motif-containing 29 antibody, tripartite motif containing 29 L homeolog antibody, TRIM29 antibody, Trim29 antibody, trim29.L antibody, trim29 antibody

Molecular Weight: 66kDa

Gene ID: 23650

UniProt: Q14134

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus