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Filaggrin antibody (AA 198-288)

FLG Reactivity: Human IHC, ISt, StM Host: Mouse Monoclonal FLG-1561 unconjugated
Catalog No. ABIN6939382
  • Target See all Filaggrin (FLG) Antibodies
    Filaggrin (FLG)
    Binding Specificity
    • 16
    • 9
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 198-288
    Reactivity
    • 65
    • 19
    • 13
    Human
    Host
    • 49
    • 23
    Mouse
    Clonality
    • 44
    • 28
    Monoclonal
    Conjugate
    • 43
    • 9
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Filaggrin antibody is un-conjugated
    Application
    • 39
    • 32
    • 25
    • 25
    • 14
    • 12
    • 9
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant human Filaggrin protein fragment (aa 198-288) (exact sequence is proprietary)
    Clone
    FLG-1561
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product FLG Primary Antibody
  • Application Notes

    Positive Control: U-251-MG cells. Skin.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    Filaggrin (FLG)
    Alternative Name
    FLG (FLG Products)
    Synonyms
    AW107830 antibody, ft antibody, FLG antibody, ATOD2 antibody, Pflg antibody, Flg antibody, filaggrin antibody, Flg antibody, FLG antibody, LOC100351762 antibody, LOC100728006 antibody
    Background
    Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
    Molecular Weight
    26-45kDa (Processed), 350kDa (Profilaggrin)
    Gene ID
    2312
    UniProt
    P20930
    Pathways
    Sensory Perception of Sound, Stem Cell Maintenance
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