FcRn antibody (AA 24-215)

Catalog No. ABIN6939380

Product Details anti-FcRn Antibody

Target: FcRn (IgG receptor FcRn (FcRn))

Binding Specificity: AA 24-215

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FcRn antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment of human FCGRT protein (around aa 24-215) (Exact sequence is proprietary)

Clone: FCGRT-2932

Isotype: IgG2b kappa

Application Details

Application Notes:

Positive Control: THP1 or HepG2 cells. Cerebellum or Testis.

Known Application: Immunohistochemistry (Formalin-fixed) (2-4 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for FcRn

Target: FcRn (IgG receptor FcRn (FcRn))

Alternative Name: FCGRT (FcRn Products)

Synonyms: FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody

Background: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.

Molecular Weight: 46kDa

Gene ID: 2217

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process