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Desmoglein 2 antibody

DSG2 Reactivity: Human WB, IF, FACS Host: Mouse Monoclonal 6D8 unconjugated
Catalog No. ABIN6939266
  • Target See all Desmoglein 2 (DSG2) Antibodies
    Desmoglein 2 (DSG2)
    Reactivity
    • 91
    • 36
    • 33
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    Human
    Host
    • 74
    • 18
    Mouse
    Clonality
    • 66
    • 26
    Monoclonal
    Conjugate
    • 40
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Desmoglein 2 antibody is un-conjugated
    Application
    • 74
    • 26
    • 22
    • 17
    • 15
    • 13
    • 13
    • 13
    • 10
    • 6
    • 6
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
    Specificity
    Recognizes a protein of 165 kDa, identified as Desmoglein-2 (DSG2). This monoclonal antibody recognizes the extracellular domain of human desmoglein-2. Desmoglein-2 is a member of the desmosomal cadherin family. Desmosomesare intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, desmogleins have R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tails of desmogleins interact with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the desmogleins with the intermediate filaments. Desmoglein-2 has been shown to be important in establishing cell-cell adhesion and function in epithelial cells. Desmoglein2 was originally identified in colon carcinoma and colon, and was named HDGC (human desmoglein colon).
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant human DSG2 protein
    Clone
    6D8
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product DSG2 Primary Antibody
  • Application Notes

    Positive Control: A431, HepG2 or K562 cells. Heart or Colon.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (0.5-1.0 μg/mL) Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    Desmoglein 2 (DSG2)
    Alternative Name
    DSG2 (DSG2 Products)
    Synonyms
    DSG2 antibody, dsc antibody, dsga antibody, si:dkeyp-51f12.6 antibody, wu:fj23f02 antibody, ARVC10 antibody, ARVD10 antibody, CDHF5 antibody, CMD1BB antibody, HDGC antibody, AA408168 antibody, D18Ertd293e antibody, desmoglein 2 antibody, desmoglein 2, tandem duplicate 1 antibody, DSG2 antibody, dsg2.1 antibody, dsg2 antibody, Dsg2 antibody
    Molecular Weight
    165kDa
    Gene ID
    1829
    UniProt
    Q14126
    Pathways
    Cell-Cell Junction Organization
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