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CPS1 antibody

CPS1 Reactivity: Human, Dog IHC, IF, StM Host: Mouse Monoclonal SPM615 unconjugated
Catalog No. ABIN6939176
  • Target See all CPS1 Antibodies
    CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
    Reactivity
    • 50
    • 29
    • 14
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Dog
    Host
    • 59
    • 6
    Mouse
    Clonality
    • 51
    • 14
    Monoclonal
    Conjugate
    • 24
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CPS1 antibody is un-conjugated
    Application
    • 27
    • 24
    • 14
    • 14
    • 9
    • 9
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF), Staining Methods (StM)
    Specificity
    This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC's occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
    Purification
    Purified by Protein A/G
    Immunogen
    Recombinant human CPS1 protein
    Clone
    SPM615
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CPS1 Primary Antibody
  • Application Notes

    Positive Control: HeLa cells. Liver or Hepatocellular Carcinoma (HCC).

    Known Application: Immunofluorescence (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 1 mM EDTA, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Expiry Date
    24 months
  • Target
    CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))
    Alternative Name
    CPS1 (CPS1 Products)
    Synonyms
    CPSASE1 antibody, cps antibody, 4732433M03Rik antibody, CPS antibody, D1Ucla3 antibody, Cps1 antibody, carbamoyl-phosphate synthase 1 antibody, carbamoyl-phosphate synthase 1 L homeolog antibody, carbamoyl-phosphate synthetase 1 antibody, peptidase M20 domain containing 1 antibody, CPS1 antibody, Cps1 antibody, cps1.L antibody, cps1 antibody, PM20D1 antibody
    Molecular Weight
    ~165kDa
    Gene ID
    1373
    UniProt
    P31327
    Pathways
    Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process
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