CPA1 antibody

Catalog No. ABIN6939171

Product Details anti-CPA1 Antibody

Target: CPA1 (Carboxypeptidase A1 (Pancreatic) (CPA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CPA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogen: Recombinant full-length human CPA1 protein

Clone: CPA1-2711

Isotype: IgG kappa

Application Details

Application Notes:

Positive Control: Pancreas.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for CPA1

Target: CPA1 (Carboxypeptidase A1 (Pancreatic) (CPA1))

Alternative Name: CPA1 (CPA1 Products)

Synonyms: cpa1 antibody, cbpa1 antibody, CPA antibody, CPA1 antibody, 0910001L12Rik antibody, Cpa antibody, carboxypeptidase A1 antibody, pancreatic carboxypeptidase A1 antibody, Carboxypeptidase A1 antibody, carboxypeptidase A1-like antibody, carboxypeptidase a1 antibody, carboxypeptidase A1, pancreatic antibody, CpipJ_CPIJ007169 antibody, CpipJ_CPIJ010802 antibody, CpipJ_CPIJ010805 antibody, MCYG_06789 antibody, MGYG_03840 antibody, cpa1 antibody, cbpa1 antibody, LOC100224866 antibody, CPA1 antibody, Cpa1 antibody

Background: Human pancreatic procarboxypeptidase A exists as three different active forms, two of which are designated carboxypeptidase A1 (CPA1) and carboxypeptidase A2 (CPA2). CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.

Molecular Weight: 47kDa

Gene ID: 1357

UniProt: P15085