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Cadherin-16 antibody (AA 371-507)

CDH16 Reactivity: Human ELISA, IHC (f), Coat Host: Mouse Monoclonal CDH16-2448 unconjugated
Catalog No. ABIN6939023
  • Target See all Cadherin-16 (CDH16) Antibodies
    Cadherin-16 (CDH16)
    Binding Specificity
    • 8
    • 8
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 371-507
    Reactivity
    • 87
    • 40
    • 31
    • 22
    • 21
    • 1
    • 1
    • 1
    Human
    Host
    • 55
    • 33
    • 1
    Mouse
    Clonality
    • 46
    • 43
    Monoclonal
    Conjugate
    • 50
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Cadherin-16 antibody is un-conjugated
    Application
    • 41
    • 37
    • 37
    • 36
    • 24
    • 19
    • 12
    • 6
    • 3
    • 3
    • 1
    • 1
    ELISA, Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Coating (Coat)
    Specificity
    This MAb recognizes a protein of 130 kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
    Cross-Reactivity (Details)
    Human,
    Purification
    200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
    Immunogen
    Recombinant fragment (around aa 371-507) of human CDH16 protein (exact sequence is proprietary)
    Clone
    CDH16-2448
    Isotype
    IgG2b
    Top Product
    Discover our top product CDH16 Primary Antibody
  • Application Notes

    Positive Control: Normal kidney or renal cell carcinoma.

    Known Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-80 °C
    Storage Comment
    Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
    Expiry Date
    24 months
  • Target
    Cadherin-16 (CDH16)
    Alternative Name
    CDH16 (CDH16 Products)
    Synonyms
    cadherin 16 antibody, CDH16 antibody, Cdh16 antibody
    Background
    Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody,Ksp-Cadherin / CDH16 (Renal Cell Marker)
    Cellular localisation: Cell Surface and Cytoplasmic
    Molecular Weight
    130kDa
    Gene ID
    1014, 513660
    UniProt
    O75309
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