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PPP3R1 antibody

PPP3R1 Reactivity: Human IHC (f) Host: Mouse Monoclonal CALNB-2342 unconjugated
Catalog No. ABIN6938230
  • Target See all PPP3R1 Antibodies
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Reactivity
    • 28
    • 14
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 22
    • 6
    Mouse
    Clonality
    • 22
    • 6
    Monoclonal
    Conjugate
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP3R1 antibody is un-conjugated
    Application
    • 15
    • 12
    • 7
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length Calcineurin B protein
    Clone
    CALNB-2342
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product PPP3R1 Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Alternative Name
    PPP3R1 (PPP3R1 Products)
    Synonyms
    si:ch211-274c22.8 antibody, canb antibody, CALNB1 antibody, CNB antibody, CNB1 antibody, CaNB1 antibody, Cnb1 antibody, MCIP1 antibody, protein phosphatase 3, regulatory subunit B, alpha a antibody, protein phosphatase 3 regulatory subunit B, alpha S homeolog antibody, protein phosphatase 3 regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) antibody, ppp3r1a antibody, ppp3r1.S antibody, PPP3R1 antibody, Ppp3r1 antibody
    Background
    Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1,Calcineurin B / PPP3R1
    Cellular localisation: Cytoplasmic and Cell Surface
    Molecular Weight
    19kDa
    Gene ID
    5534, 280604
    UniProt
    P63098
    Pathways
    RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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