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PPP3R1 antibody

PPP3R1 Reactivity: Human IHC (f) Host: Mouse Monoclonal CALNB-2342 unconjugated
Catalog No. ABIN6938230
  • Target See all PPP3R1 Antibodies
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Reactivity
    • 28
    • 14
    • 13
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 22
    • 7
    Mouse
    Clonality
    • 22
    • 7
    Monoclonal
    Conjugate
    • 18
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPP3R1 antibody is un-conjugated
    Application
    • 16
    • 13
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Specificity
    Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
    Cross-Reactivity (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant full-length Calcineurin B protein
    Clone
    CALNB-2342
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product PPP3R1 Primary Antibody
  • Application Notes

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Preservative
    Azide free
    Storage
    -20 °C,-80 °C
    Storage Comment
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Expiry Date
    24 months
  • Target
    PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
    Alternative Name
    PPP3R1 (PPP3R1 Products)
    Background
    Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, CNB1, PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1,Calcineurin B / PPP3R1
    Cellular localisation: Cytoplasmic and Cell Surface
    Molecular Weight
    19kDa
    Gene ID
    5534, 280604
    UniProt
    P63098
    Pathways
    RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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