PMEPA1 antibody

Catalog No. ABIN6938199

Product Details anti-PMEPA1 Antibody

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PMEPA1 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificity: PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, suggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.

Cross-Reactivity (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogen: Recombinant full-length human PMEPA1 protein

Clone: PMEPA1-2697

Isotype: IgG kappa

Application Details

Application Notes:

Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: SKBR-3 cells. Prostate, Breast or Renal Cell Carcinoma.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Expiry Date: 24 months

Target Details for PMEPA1

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Alternative Name: PMEPA1 (PMEPA1 Products)

Synonyms: Tmepai antibody, PMEPA1 antibody, TMEPAI antibody, zgc:92731 antibody, tmepai antibody, STAG1 antibody, 2210418I02Rik antibody, AW455466 antibody, Erg1.2 antibody, N4wbp4 antibody, Stag1 antibody, prostate transmembrane protein, androgen induced 1 antibody, prostate transmembrane protein, androgen induced 1 L homeolog antibody, Pmepa1 antibody, PMEPA1 antibody, pmepa1 antibody, pmepa1.L antibody

Background: PMEPA, PMEPA1, Prostate transmembrane protein, androgen induced 1, Solid tumor-associated 1 protein, STAG1, TMEPAI, Transmembrane prostate androgen-induced protein, Transmembrane, prostate androgen induced RNA,PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein)
Cellular localisation: Cell Surface and Cytoplasmic

Molecular Weight: 32kDa

Gene ID: 56937, 517155

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway